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The analysis of detected modules by the present algorithm suggests that most of these modules have well biological significance in context of complexes, suggesting that the roles of edges are critical in discovering protein complexes.
In the context of complexes formed with DNA1-H_OH, the magnitude of r2 as well as the dependence of r2 on opposing force is altered by the Y254V mutation in D12A/D66A/Y254V complexes, relative to D12A/D66A complexes.
The 'contributes_to' qualifier is specifically intended for the annotation of functions that occur in the context of complexes, rather than being an activity of a single subunit within the complex.
Further, the analysis of detected modules by the present algorithm suggests that most of these modules have well biological significance in context of complexes, suggesting that the roles of edges are critical in discovering protein complexes.
The decrease in r2 is similar to the ∼1.75 2-fold ∼1.75 2-foldr2 observedecreasee Y254 mutatinn in the context of complexes for2ed with DNA1-H_H and wild-type observedD66A enzymes.
The idea of balance is natural in itself, in the context of complexes, and is also naturally extensible to signaling and transcriptional networks where there are often clearly opposed actors (i.e. a protein kinase "versus" a phosphatase [ 6]).
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Similar observations were made when the median length of proteins was studied in the context of complex complexity [Additional file 5].
However, since the number of possible pairwise dependencies grows quadratically with the number of entities, the complexity is not manageable in the context of complex traffic situations.
van Vliet J, Oates NA, Whitelaw E. Epigenetic mechanisms in the context of complex diseases.
This paper explores the concept of technological paradigms in the context of complex technical systems.
The theory is formulated in the context of complex conductivity under harmonic loading.
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