Modeling spatial processes with ordinary differential equations has been used successfully before, mainly in the context of compartment models.
Interactions between bacteria and the inflammatory response are defined within the context of two lumped compartments that are assumed to be well-mixed, and thus there is no spatial component in this present model.
Our results demonstrate that the incidence of clonal hemopoiesis is much higher than suggested by exome-sequencing studies, that spliceosome gene mutations drive clonal outgrowth primarily in the context of an aging hemopoietic compartment, and that NPM1 mutations do not drive ARCH, indicating that their acquisition is closely associated with frank leukemia.
With these constructs, transgene expression was achieved in the context of angiogenesis or the fibroblast compartment of tumor stroma, respectively.
Metabolomics studies the occurrence and change of concentrations of small molecular weight chemical compounds (metabolites) in organisms, organs, tissues, cells and ultimately cell compartments in the context of environmental changes, disease or other boundary conditions.
In the context of observing the dynamics of multiple compartments, Bayesian methods provide efficient tools for model inference and selection.
HDL particles may also easily be redistributed from the intravascular to the extravascular compartment in the context of sepsis [13, 24].
The absence of sessile hemocytes in eater null larvae provide a unique tool to assess the function of the sessile compartment in the context of development, peripheral nervous system stimulation (Makhijani et al., 2011) or immune challenge (Márkus et al., 2009).
In this context, the conceptual and mathematical models of TOCATTA-χ have been designed to be relatively simple, minimizing the number of compartments and input parameters required.
