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Do we want to see Monet's Water Lilies solely in the context of a mouse mat?
Using humanized PPARα mice, it has been shown that the human PPARα receptor has the ability to induce peroxisome proliferation and peroxisomal fatty acid oxidation in the context of a mouse liver [34], [35].
Our results demonstrating synergistic effects of reduced chaperones in the context of a mouse model for AD highlights the in vivo importance of sHsps in diseases characterized by protein misfolding and aggregation.
In the context of a mouse model of colitis-associated CRC, Limk2 deletion increases dysplasia and intestinal tumour size.
In the context of a mouse model for tumor necrosis factor alpha-induced cardiomyopathy, it was found that increased expression of TNF-alpha leads to degradation and changes in the subcellular distribution of desmin and to pathological aggregate formation.
Library 3 (phase 3; template = C1A4E + Q18L/K33N/F54I/F68Y/L72Q/M75K/I90V) was screened in the context of a mouse Id-X-HaloTag (where X = library) using coelenterazine and furimazine.
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To investigate the consequences of increased mitochondrial oxidative stress in the context of an established mouse model of AD, we crossed the Tg2576 mouse to mice heterozygous for sod2, a model of mild mitochondrial oxidative stress [9], [51], [52].
Because we were interested in testing the function of the gene-trap tTA vector in the context of an endogenous mouse gene, carriers of insertions 02A-0001 and 02A-0002, both in mouse genes, (Fig. 3A) were propagated for further study.
In some contexts, as many as 25,000 cells contribute to a given malignancy following tail vein injection, and, consequently, nearly 25,000 loss of function phenotypes can be screened in the context of an individual mouse.
The RAF family of kinases, which function downstream of Ras in the Ras-MAPK signaling pathway, have also been implicated in glioma, and studied in the context of the RCAS/Ntv-a mouse model.
This situation might be reminiscent to what we observed previously in the context of a SCA7 retinal mouse model, where alteration of the neuronal differentiation program by mutant ataxin-7 appeared to be stress-induced [15], [46], [61].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com