However, an important aspect in this context is the level of expression regulation at which MSL-C acts.
However, 15-PGDH, the enzyme responsible for the degradation of PGE2, has received little attention in this context, although its level of expression ultimately determines the availability of PGE2.
We find that all "Information storage and processing" categories have a higher level of expression context conservation than all "Metabolism" categories.
'Off-context' factors were defined by a level of expression in at least one non-lymphoid normal tissue that was greater than 10-fold the median expression value across all of 79 normal tissues/cell types.
For example, its spot may not hybridize well and the level of expression, co-expression or even expression context of the gene will be correspondingly influenced.
Clearly, the biological outcomes of EP2 and EP4 activation are very context dependent, involving levels of expression of the EP (and other interacting) receptors, ligand, as well as cross-talk among the EP and other receptors.
Level of expression (general prominence) ('LoE').
To the extent that genes such as these have been subject to selection in the context of lower or higher levels of expression during primate evolution (e.g., Khaitovich et al. 2006), their altered expression may thus be especially likely, compared to other genes, to cause maladaptive effects on neurodevelopment that affect social behavioral phenotypes.
It is currently unclear why such variability is observed in flies; however CTG tract sizes, expression levels and context of expression may all contribute to the differences in the observed phenotypes.
In this context, a high level of mCherry expression showed enrichment for neural progenitors, while lower mCherry corresponded with more committed neural states.
