Mutation context of wild type versions of AID and APOBEC3G are shown in Figure 3 figure supplement 1. Analysis of additional yeast transformants and breast cancers is shown in Figure 3 figure supplements 2 4.
Contextual fear conditioning has previously been carried out with the huAPP/PS1 mice where 11-month-old AD mice spent significantly less time freezing in response to the context than wild type controls [ 44].
For these mutants, generated in the context of unconstrained wild type GltPh and inward cross-linked GltPhin, we measured the dependence of L-asp dissoconstantconstaNa+on Na+ concentration.
Parallel experiments were conducted in different genetic contexts: the wild type strain and knock-out (KO) strains in which the genes coding for different transcription factors connected to drug response, YAP1, PDR1, PDR3, and YRR1, were deleted.
This substitution behaved as deleterious in both the presence and the absence of AZC when it was present in the mutational context of the wild type virus (Table 4), and, however, it could be propagated when it was present in the mutational context of substitution A1746U.
To study the consequences of CSD in a migraine-relevant context, we measured cortical gene expression profiles in FHM1 and wild-type mice 24 hours after CSD induction.
This is put into context by comparing the ratio of fold change between vhl and wild-type.
The ability of the Herpes simplex virus type 1 (HSV-1) immediate early protein ICP0 to inhibit IRF3 is controversial and has not been studied solely in the context of a wild type HSV-1 infection.
In addition to illuminating cytoprotective features of autophagy in response to cellular damage, this screen establishes a genetic methodology for investigating cell biological phenotypes in live cells, in the context of viable wild type organisms.
However, in a context where even wild type RSV infections fail to induce a strong long lasting protective immunity, these recombinant RSV vaccines, which can be less immunogenic than the wild type virus because of attenuation, may not bring the final clue to the issue of RSV vaccination.
