This contentious hypothesis is the focus of clinical and laboratory research, but remains unproven.
Such a connection, however, is a highly contentious hypothesis among geologists, who remain uncertain about both the trajectory of the Indian land mass and the time of its collision with modern Asia, which drove up the Himalayan plateau, he said.
Despite yielding groundbreaking conceptual advances, this vast treasure trove of data has also been the source of contentious hypotheses.
Rather than attempting to explain aging as the consequence of degeneration of single pathways, a conceptual framework consisting of a network of affected processes not only reconciles different, at times contentious hypotheses regarding aging mechanisms, but will ultimately lead to an integrated view of these processes and to a more accurate understanding of the molecular basis of aging.
Those reasons remain contentious, but hypotheses include memory consolidation, learning improvement, tissue repair, and energy conservation.
The effect of homologous recombination (HR) on the evolution of microbial genomes remains contentious as competing hypotheses seek to explain the evolutionary dynamics of microbial species.
However, this hypothesis remains contentious.
Although this hypothesis is contentious [ 1, 8], it is worth verifying because this is the leading explanation for the acquisition of cyanobacterial genes through secondary endosymbionts in Heterolobosea.
Regarding soft tissue infections related to heroin-associated anthrax, the role of surgery was initially unclear, and the suggestion was made that disturbing a lesion may result in clinical deterioration, although this hypothesis remains contentious (20, 21, 24 ).
One reason why the hypothesis remains contentious is partly due to the fact that Braak staging and severity of PD symptoms do not always correlate 8. Certainly, some individuals with relatively severe α-syn pathology discovered post-mortem were never diagnosed clinically with PD prior to death 66.
However, the 2R hypothesis has remained contentious (Hokamp et al., 2003; Hughes and Friedman, 2003).
