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The oil content of the formulation can vary.
The proportion of the drug, chitosan and sodium alginate content of the formulation significantly influenced the in vitro dissolution of the model drug (paracetamol).
Hence, the PM is a useful inactive ingredient to produce various types of control-released system of insulin by making just a few changes in PM content of the formulation.
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The median size of the pellets of the "good formulation" could only be related to the chitosan and sodium alginate content of the formulations.
The carbohydrate content of the formulations was measured by anthrone method [28].
The dry matter (DM) content of the formulations ranged between 20.1 % for Ryzoset and 62.2 % for Manek, and in contrast, ash contents of the formulations were between 1.5 % (Rygex) and 15.4 % (Algavyt Zn/Mn) (Table 2).
However the study evidenced that sodium alginate and Acrycoat E30D do not have much significant effect in the drug content of the formulations, since the drug contents were within ±5% of the labelled potency of the drug in all the formulations.
Content of the formulations of amoxicillin and co-trimoxazole was measured by dissolving each formulation in solvent (0.1 M HCl for amoxicillin and methanol for co-trimoxazole) to give a 1 mg/mL solution that was further diluted to obtain a 0.5 mg/mL solution, and analyzed using our in-house HPLC method outlined above.
In these studies, drug content, pH of the formulation was evaluated and formulation found to be stable also in physical appearance when stored for 3 months [ 13, 15].
The active ingredient contents of the formulations reached up to 28% w:w.
The carbohydrate contents of the formulations ranged between 1.2 (Manek) and 35.35 (Algavyt, Table 2).
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