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Drug content, encapsulation efficiency and particle properties such as size, size distribution (polydispersity index) and zetapotential were determined.
Orthogonal design was used to optimize the formulation according to drug content, encapsulation efficiency and burst effect.
The drug-loading content, encapsulation efficiency, particle size, and zeta potential of the final optimized nanomicelles were 4.58%, 97.20%, 30.21 nm and −0.84 mV, respectively.
To optimize the preparation technology, we investigate the effects of dosage, type of organic solvent, hydration temperature and time, and cryoprotectant on drug-loading content, encapsulation efficiency, particle size, and zeta potential.
Table 2 The drug loading content and encapsulation efficiency of Sal NPs prepared by different methods Drug loading content Encapsulation efficiency Sal-loaded SE-NPs 89.70 ± 5.7 8.12 ± 5.7 Sal-loaded NR-NPs 81.51 ± 8.9 7.40 ± 8.9 Sal, salinomycin; SE-NPs, nanoparticles prepared by single emulsion method; NR-NPs, nanoparticles prepared by nanoprecipitation method.
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The drug-loading content and encapsulation efficiency of P5kSSLV-DOX nanomicelle were investigated by UV.
Meanwhile, the drug content and encapsulation efficiency of nanoparticles can be achieved by varying the feed weight ratios of PLGA and DOX particles.
The independent variables studied were O-CMCS/CHE ratio, O/W phase ratio, and O-CMCS concentration, dependent variables (responses) were drug loading content and encapsulation efficiency.
The hydrodynamic diameter of the prepared SPION-evodiamine-loaded nanocarrier was approximately 261 nm, and the drug-loading content and encapsulation efficiency were 8.61 ± 0.73% and 40.36 ± 3.42%, respectively.
Effect of these parameters was investigated on shape, size, weight, weight loss (WL), moisture content (MC), encapsulation efficiency (EE), drug loading (L), and drug release pattern of the microparticles.
Drug content and encapsulation efficiency were determined for all the formulations.
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