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Today, the field of contemporary toxicity testing needs well-validated suites of cellular systems that examine relevant biomarkers for critical physiological effects (Eisenbrand et al. 2002).
An NRC report, "Toxicity Testing in the 21st Century: A Vision and A Strategy" discussed challenges for contemporary toxicity testing for chemicals in commerce other than drugs (National Research Council, 2007; Krewski et al., 2010).
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Indeed, "The Twilight of American Culture" is an impassioned indictment of contemporary life: the "toxicity" of corporate capitalism, the "nakedly sick" enterprise of deconstruction, the poor spelling of public signs and the "incomprehensible" conversation overheard on a Greyhound bus.
In general, the main problem in contemporary drug development is toxicity [ 34].
It is evident that contemporary acute and chronic toxicity studies are not protective of future generations.
Dose escalation in this setting has been demonstrated to improve biochemical control with acceptable toxicity using contemporary radiotherapy techniques.
Furthermore, treatment-related toxicity with contemporary TT remains considerable as 45 patients (39.5%) had their dose reduced and 26 patients (22.8%) discontinued sunitinib entirely.
Dose escalation in this setting has been demonstrated to improve biochemical control with acceptable toxicity using contemporary radiotherapy techniques [ 3, 4].
We therefore hypothesized that ACR adduction of these regulatory residues might cause presynaptic toxicity, although some contemporary research did not support this idea (e.g., Martenson et al. 1995).
There is significant diversity in B toxicity tolerance among contemporary Australian barley varieties but this is not related to variation at any of the four known B tolerance loci, indicating that novel, as yet undiscovered, sources of tolerance exist.
Available data suggest that, when used according to contemporary guidelines and with appropriate monitoring for toxicity, conventional nonbiological treatments can be reasonably safe and tolerable [ 29].
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