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Our study has many strengths including being, to our knowledge, the largest validation study of severity-of-illness scores in Brazil and using more contemporary data from several centers countrywide.
Given changes in academic medicine, the deficiency of contemporary data from multiple institutions, and the absence of data from pediatrics we performed an observational study of rounds encompassing internal medicine and pediatrics at two academic institutions.
Finally, it should be noted that contemporary data from NIS are typically 3 years old making descriptions of current or past year trends impossible.
Moreover, these studies were usually carried out in high-income countries and very few contemporary data from emerging countries are available [ 10- 12].
Using contemporary data from a large multicenter database, the current analysis assessed short- and long-term AHF-related outcomes by WRF status using a rigorous clinically-based definition for WRF.
However, the small number of ancient samples and sampling locations, coupled with the lack of contemporary data from north-western Europe due to population extinction, prevent a more detailed insight into the wolf demographic history.
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In the contemporary data, deaths from cardiovascular causes arise in the elderly and deaths from suicide in the young.
It is a first report covering both historical and contemporary data drawn from one geographical area, with comprehensive patient ascertainment.
Contemporary data derived from screening programmes have been used to define more optimal/individualised screening intervals [ 8– 14, 22, 23].
Therefore, we only used contemporary data drawn from locally based surveillance systems, population-based studies, and surveys (Table 5) (4) in these analyses.
Our study adds to prior literature by identifying barriers and facilitators to retention in care using contemporary data collected from a diverse population of HIV-infected individuals.
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