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Second, although we cannot definitively rule out the possibility of a pseudo-outbreak from laboratory contamination of specimens, C. neoformans, unlike environmental molds, is not typically a laboratory contaminant.
(1) Contamination of specimens with exogenous DNA can occur prior to and during handling.
Wearing gloves to prevent cross contamination of specimens, we inspected all skin on legs, feet, and around bills, and lightly ruffled feathers to expose other nodules.
Contamination of specimens with mouse DNA will produce a false positive PCR result since mouse DNA contains endogenous MLV sequences that amplify by the diagnostic XMRV/MLV PCR assays.
Particular care was taken to prevent external contamination of specimens, including through the meticulous cleaning of venipuncture site.
Care was also taken at all stages to avoid contamination of specimens, especially at the stage of DNA tissue extraction.
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The possible contamination of specimen DNA that consists of cancer along with mesenchymal cells, such as fibroblasts or lymphocytes, may therefore cause inaccurate results.
Contamination of specimen could lead to a false-positive result.
Extreme caution was taken to prevent cross-contamination of specimens.
During the splitting procedure cross-contamination of specimens may have occurred whereby HIV antibody results became false-positive upon subsequent testing.
Cross-contamination of specimens during collection and transportation was avoided by using different sets of sterile instruments and containers for each case sampled.
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