They are potentially safer than current therapies because they contain a modification of an endogenous naturally occurring protein.
The APL identified was not modified at the TCR contact sites but contains a modification at the key MHC anchor position.
The data is displayed as the ratio of the percentage of minichromosomes that contain a modification following treatment divided by the percentage of untreated minichromosomes containing the same modification.
Because of the wealth of genomic information on RNAs, a unique aspect of RNA modification mapping is that complete RNA sequencing by mass spectrometry is not required one simply seeks to identify those sequence locations that contain a modification.
They are potentially safer than current therapies because they contain a modification of an endogenous naturally occurring protein, used to interrupt the autoimmune T cell attack and allow for tissue repair.
APLs are potentially safer than existing therapies because they contain a modification of an endogenous naturally occurring protein, used to arrest the autoimmune T-cell attack and allow tissue repair.
This strain contains a modification in the polymerase gene (NS5A), which for reasons that are incompletely understood has permitted the generation of chimeras representing all of the HCV genotypes that are infectious in culture.
A phosphorothioate RNA contains a modification that substitutes either the pro-Rp or the pro-Sp nonbonded phosphate oxygen (pro-Rp/Sp OP) by a sulfur atom and significantly alters the chemical shift of the associated P signal such that it can be easily identified in a 1D P NMR spectrum.
We previously found that chemically modified derivatives of DIF-3 such as butoxy-DIF-3 (Bu-DIF-3), which contains a modification at the methoxy group (Fig. 1A), are more potent anti-proliferative agents than DIF-3 in K562 cells (Gokan et al., 2005).
The AO had a central segment containing a phosphorothioate modification and the adjoining segments phosphorothioate plus 2′-O-methyl modifications [56].
Compared with wild-type GITR-Ig, treatment of primary AML and CLL cells with mutants containing a S239D/I332E modification potently increased cytotoxicity, degranulation, and cytokine production of NK cells in a target-antigen dependent manner witarget-antigen dependentg observed with CLL cells upon parallel exposure to Rituximanner
