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The fragments contained consensus sequences for each target gene at both ends; therefore, they were inserted into the chromosomal DNA of the host cells through homologous recombination.
Sequence analysis showed conserved five iron binding sites in the LOX domain of all the Rc-LOX, however, only LOX5 contained consensus (positions 547, 556, and 715) histidines residue.
Of the putative SUMOylated substrates identified, HIPK3 [23] and RNF4 [13] were previously shown to bind SUMO1 and the majority of the remaining substrates contained consensus SUMO1 targeting sequences (yKxE/D) [24].
As shown in Figure 9, the promoters of these transcription factors contained consensus RBP-J binding sites, thus supporting a model by which Notch signaling influences lineage decisions by directly activating key transcriptional regulators involved in cell lineage determination (see model below).
All splice donor/acceptor sites contained consensus GT/AG dinucleotides.
All splice donor/acceptor sites contained consensus GT/AT dinucleotides.
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In particular, the SLC6A3 UTRs contain consensus sequences recognizable by eight miBridge' miRNAs, while the SLC6A4 UTRs contain consensuses for 4 miRNA of this class.
In human genomic DNA, only three positions in MKK3 contain consensus sequences for REX1 binding.
The target antigen is a branched peptide containing consensus gp41 sequences from multiple HIV-1 subtypes [21].
Deoxyribonucleotides probes containing consensus glucocorticoid response element (GRE): 5-CTAGGCTGTACAGGATGTTCT-GCCTAG-3 and 5-CTAGGCAGAACATCCTGTACAGCCTAG-3 were synthesized and annealed.
It is also straightforward to develop designer vaccines that contain consensus sequences capable of inducing antibody that cross-neutralizes drifted or shifted strains of influenza [1].
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