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Because ELMs are manually defined and thus contain specificity not necessarily found within the known instances themselves, ELMred definitions were used that should, in principle, be possible to discover (normalized IC ≥ 2.0, 3+ non-homologous occurrences).
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These observations provide formal proof that the disease associated autoantibody repertoire contains specificities that can participate in the development of demyelinating lesions.
Type I DNA methyltransferases contain one specificity subunit (HsdS) and two modification subunits (HsdM).
For each structural superclass one SVR model was derived from the training datasets that contain binding specificity data (PFMs).
Type I RM systems contain the specificity (S) subunit that determines their recognition sequence and is necessary for both restriction and modification activities (Fig. 1B) [8].
There is one clear tendency in the SDPclust performance: all families, for which SDPclust performs significantly worse than SDPsite, contain 2 specificity groups (as defined by EC numbers) and a relatively small numver of sequences (<25).
However, if fusion occurs between strains that contain alternative specificities at heterokaryon incompatibility (het) loci, either the fusion cell is walled off and rapidly killed or the growth of the heterokaryon is inhibited (Glass and Kaneko 2003; Aanen et al. 2010).
For each network, let S be a vector containing the specificity of impacts of each phage and R a vector containing the specificity of associations.
with similar results, indicating reagents labeled as "anti-CRP" have a high probability of containing dual specificity to both the pCRP and the mCRP antigen (Samberg et al. 1988).
CstF stimulates the activity of the basic mRNA 3' processing complex that also contains Cleavage/Polyadenylation Specificity Factor (CPSF) and Poly(A) Polymerase (PAP).
The HCV_s43 module mainly contains dual specificity protein phosphatases, heat shock proteins (HSPs), crystalline proteins and mitogen-activated protein kinases (MAPKs).
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