Inhibition of brain Aβ production was improved by one of the compounds containing constrained modification.
In order to unravel the intricate history of tRNA, we explored competing (alternative) or non-competing phylogenetic hypotheses by reconstructing sub-optimal trees containing constrained monophyletic groupings of taxa [27].
We assessed the effectiveness of our SVM-based approach to detect selective constraint by performing forward simulations of functional 10 kb windows containing constrained elements of various sizes, and experiencing varying strengths of negative selection, as well as nonfunctional 10 kb windows evolving entirely under drift.
But at least until her old age, her so-called wildness was contained and constrained.
It is to contain and constrain what the lesser powers see as excessive clout on the part of No. 1.
And Rohmer learned to keep his distance, but there's fire at the heart of his reserve, and the best way to see his films is to look for the wild man contained, even constrained, beneath their placid yet taut surfaces.
Inhibitors 3b and 3c, containing conformationally constrained cyclic ethers, displayed impressive enzymatic and antiviral properties and represent promising lead compounds for further optimization.
These data provide yet another striking example of the superiority of protein ligands containing conformationally constrained units relative to simple peptoids.
If we wish to force the solution to pass through particular locations, this can be expressed in the constraint A β = c, where the columns of the matrix A evaluate the basis functions at the constraint locations and the vector c contains the constrained response values.
Linear regression analysis, including likelihood ratio tests between full (containing genotype and covariates) and constrained (containing covariates only) models, were performed to estimate the proportion of variance in volumetric measurements attributable to each SNP's genotype.
