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Virtually all IMPDHs contain a subdomain.
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The authors aligned subunit II of cytochrome c and quinol oxidases and found that the C-terminal of both proteins contained a subdomain in a Greek key β-barrel scaffold.
The resulting phylogenetic relationships showed that each of them contained A-E subdomains (Additional file 1: Figure S2), which is consistent with the results previously reported [ 31, 32].
The Y-family DNA polymerases differ structurally from the enzymes in the other families in that the Y-family enzymes contain a unique subdomain termed either the little finger (LF) domain or the polymerase-associated domain (PAD) in addition to the canonical finger, thumb, and palm subdomains.
The MERS-CoV RBD contains a core subdomain and a receptor-binding subdomain.
Most ELKs also contain a C-terminal helical subdomain directly following subdomain IX, which EPKs lack.
For fold simulations, the initial geological surface defining the boundary condition will contain a significant number of subdomains.
These subdomains also contain a low density of transcribed genes (Yan et al. 2005, 2006).
Two members contain a repeat region inserted between subdomains III and IV consisting of 90 copies of the H K S/N D N/H/S N hexapeptide in PFD1175w and of 32 copies of the two amino acid motif NE/G in PFI0125.
The N-terminal CR1 contains a Ras-binding subdomain and a cysteine-rich subdomain, both required to bind to activated Ras (Ras-GTP) at the cell membrane.
A protein fragment encoded by this exon (amino acids 204 249) contains a part of subdomain VII (starting from conserved Asp204 which is important for γ-phosphate of MgATP orientation), the entire subdomain VIII, which is critical for substrate recognition, and a portion of subdomain IX of the Hunk protein kinase catalytic domain.
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