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Since these are most likely to occur when individuals are at the edge of the detection range [24], all one-second contacts were removed prior to data analysis.
The steric clashes and bad contacts were removed using What-If server.
Spurious contacts were removed through a four-tier set of 45000 energy minimization steps.
The initial unfavorable atomic contacts were removed by energy minimization with 1500 steps.
Two independent variables (age of index case-patient and exposure duration of close contacts) were removed in the stepwise regression equation.
In further preparation steps bad contacts were removed, bond lengths were optimized, disulfide bonds were created, protein terminals were capped and selenomethionine residues were converted to methionine.
Similar(52)
The use of several snapshots ensures that, first, the model-built (AChEt) structure has become sufficiently relaxed that any remaining bad contacts are removed.
In a sensitivity analysis this "repair mechanism" is only performed annually instead of daily (resulting in lower network turnover); or an additional random percentage of contacts is removed and replaced by new random contacts (resulting in higher network turnover).
Those curves displaying significant noise due to the presence of gas bubbles in the liquid cell (evident as large plateaus), interference between light reflected from the cantilever and mineral surfaces (evident as periodic oscillations), or a steep positive or negative slope in the region of no contact were removed from the data set.
This increased to 65% when individuals who had died or refused further contact were removed.
One person can choose another person as his contact only once and the relation remains in the same state until the contact is removed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com