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Through these contacts, mediator assists the recruitment of RNA polymerase II to genes promoters and integrates regulatory signals for transcription (Conaway and Conaway 2011).
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Our data suggest that when Med31 is lacking and TREX-2 is unable to contact Mediator, Cdk8 cannot properly exert its influence on TFIIH.
By contacting Mediator, TREX-2 utilizes Mediator's known ability to integrate external signals like transcription factors and co-activators and directly communicate them to the general Pol II machinery.
Several EMT activators act either jointly or independently on each of these cell contact mediators and their impact on cell-cell junctions is nearly the same regardless of cell type [5].
The negotiator contacts access mediator (i.e., GENI clearinghouse) to start bilateral negotiation (i.e., automatic trust negotiation).
These data have established the importance of both cell-cell contacts and mediators for the production of the inflammatory activity.
If you've tried to be nice about it and negotiate, consider contacting a mediator.
The heterogeneity of Mediator contacts with RNAPII suggests a dynamic exchange at actively transcribed genes.
Thus, they might represent secondary adaptations for increased inter-subunit contacts within the Mediator complex.
"Then they said they wanted to return to Japan, so the mediator contacted the Japanese embassy".
Robert Batterman, the museum's chief negotiator, said in an interview that he contacted a federal mediator last week to tell her that the museum thought it was time for her to bring the two sides together.
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