The matrix shows that contact intensity for all contacts tends to be highest in the diagonal, demonstrating an assortative mixing pattern where the greatest contact is between individuals of a similar age group.
Contact intensity is improved by increasing surface contact and by stirring.
More importantly, we did not collect information on contact intensity and duration.
To gain more insight in factors determining contact intensity (physical contact, location, frequency and duration), the binary classification tree methodology as introduced by [ 15] was used.
The average contact intensity between pairs of elements within active domains is two-fold higher compared to passive domains, with a higher variance.
This parameter summarizes multiple aspects of transmissibility, including the contact intensity between persons, duration of infectiousness, and the host's susceptibility to the infectious pathogen (12, 13 ).
These data suggest that household transmission can be prevented by decreasing the contact intensity through measures such as home quarantine [ 30].
Earlier studies explicitly linked contact intensity and duration with infection risk and showed their importance for understanding transmission dynamics [ 40, 41].
Although already referred to in the general considerations affecting the performance and efficiency of an extraction system, mention should again be made of the temperature of extraction and the contact intensity between material and liquid.
Figure 2 shows contact intensity distributions in- and outside households: close or non-close (left figure); duration (middle panel); frequency (right panel), clearly indicating that most intense contacts (darker shading) take place with household members.
We focussed on pairs of cohesin/CTCF binding sites (separated by 100 200 Kb) and computed the mean Hi-C contact intensity between all 2 Kb genomic bins located up to 40 Kb upstream and downstream of each binding site.
