However, critical protein ligand interactions and their quantitative contribution to inhibition potency are still largely uncharacterized for broader groups of AIs, in particular for the hydrophobic contact and coordination to the heme iron in the active site.
Three scales (first contact, continuity, and coordination) in PCAT were split into five scales (first contact and continuity, first contact (access), coordination, the same doctor, and stableness) in the PCAT-T and one scale (comprehensiveness) in PCAT was represented by two scales (comprehensiveness (medical care) and comprehensiveness (social care)) in the PCAT-T.
In comparisons with mechanistic powder compaction models, measurements of particle deformation, contact areas, and coordination numbers were found to substantiate the importance of the experimentally identified mechanisms.
The model revealed that hydrophobic contact and nitrogen heme iron coordination primarily determines inhibition potency of steroidal and azaheterocyclic AIs, respectively.
The hydrophobicity density field model and the smallest dual descriptor Δf(r) S were successfully used in explaining stabilization of aromatase-inhibitor complex through the hydrophobic contact and nitrogen heme iron coordination, respectively.
For the quantitative description of the effects of the hydrophobic contact and nitrogen heme iron coordination on aromatase inhibition, the hydrophobicity density field model and the smallest dual descriptor Δf(r) S were introduced, respectively.
PCAT was developed by Johns Hopkins Primary Care Policy Center and included four unique domains (first contact, longitudinality, comprehensiveness, and coordination) as well as three derivative attributes (family centeredness, community orientation, and cultural competence) [ 13].
Starfield also defines primary care as a set of functions that, in combination, are unique to primary care and characterised by four attributes; first contact, longitudinality, comprehensiveness and coordination [ 2].
The PCATools measures the presence and extent of the four core attributes (First contact, Longitudinality, Integrality and Coordination) and the three derivatives of PHC (Family orientation, Community orientation and Cultural competency) and the user's degree of affiliation with the health service.
