Sentence examples for contact suppression from inspiring English sources

These studies indicate that clinically MER may be a suitable alternative to BCG for contact suppression of tumour growth or incorporation into tumour cell:adjuvant vaccines for active immunotherapy.

One possible scenario is that the dual function of contact, which delays apoptosis of crowding tumor cells but also inhibits their proliferation combined together with contact suppression of homing genes, ultimately, directs cell spreading and tumor expansion toward less populated niche regions where the 'contactless' gene signature is supposed to be less suppressed.

They are responsible for immunoregulation predominantly through cell-cell contact mediated suppression.

Tregs require activation through the T cell receptor (TCR) [5] and cell-to-cell contact for suppression [6], [7].

EPL cells have been used successfully to define the roles of cell:cell contact, mesoderm suppression and γ-secretase in lineage choice from pluripotent cells in culture [41] [42].

Furthermore, close apposition of Tregs and Teff could facilitate this process and this may be an additional explanation for the apparently cell contact dependent suppression observed in many in vitro studies.

It is possible that binding of CA125/MUC16 to E-cadherin complexes results in the surface localisation of E-cadherin, which mediates cell contact and suppression of cell invasion.

Foxp3 + CD4 + CD25 + regulatory T cells (Foxp3 + Treg) play an anti-inflammatory role mainly through contact dependent suppression or releasing anti-inflammatory factors on other immune cells such as CD4+ and CD8 + T cells, natural killer (NK) cells and NKT cells, B cells and dendritic cells (DC) [ 7- 9].

The suppression of genes alters somatic maintenance and repair leading to altered proliferative control of gene expression, polymorphism, and contact inhibition regulation and telomere shortening [ 151].

Beyond its involvement in contact-dependent suppression, soluble TGF-β can directly inhibit T cell proliferation, suppress macrophage activation and modulate dendritic cell function in its role as an immunoregulatory cytokine.

We further demonstrated in vitro that IL-2 produced by neighboring effector T cells activated MBP-specific Tregs, initiating contact-independent suppression to T effectors in local milieu.