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To identify frequency and pattern of contact sensitization among patients with periorbital dermatitis.
The present study demonstrated that IL-1β mRNA expression was upregulated rapidly and transiently in well-defined regions of mouse epidermis and dermis during contact sensitization, and was succeeded by an elevation in IL-1β protein.
Responses to contact sensitization are decreased at day 2 after priming but increased at day 6.
Interestingly, in these mice responses to contact sensitization were decreased at day 2 after priming but increased at day 6, leading to enhanced T cell responses [33].
Some patients underwent rechallenge to evaluate contact sensitization and none displayed conclusive contact sensitization.
Several in vitro approaches have been used to characterize the contact sensitization potential of LMW compounds.
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Results of this second study indicated a low potential for contact-sensitization reactions for both tazarotene foam and vehicle foam.
10 Two single-center, evaluator-blinded, randomized, vehicle-controlled, Phase I patch studies were performed to evaluate tazarotene foam 0.1% for cumulative irritation potential and contact-sensitization potential.
In the contact-sensitization study, patches of either tazarotene 0.1% or vehicle foam were applied on participants' backs for a 3- week induction phase (three times per week for 48±2 or 72±2 hours), followed by a 1-week challenge and a 2-week rechallenge phase (single 48-hour application) at the investigators' discretion with interim 2-week rest periods.
For such reasons, chemicals identified as contact sensitizers are often suspected of posing a potential for respiratory sensitization.
HCA was classified as a contact sensitizer serving as a positive control in the LLNA and tested in other in vitro sensitizations tests [15], [38].
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