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OE mediated dendritic elaboration could be through a cell cell contact mediated mechanism or via the trophic activity of diffusible factors released from OE explants.
Zimmer, M., Palmer, A., Kohler, J. & Klein, R. EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion.
They are responsible for immunoregulation predominantly through cell-cell contact mediated suppression.
In human skin NHKs and HDFs are separated by the basement membrane (BM), thus rendering epidermal-mesenchymal cell-cell contact mediated mechanisms less possible [19] [20].
Studies employing in vitro co-culture systems demonstrated that mesenchymal cells induce endothelial quiescence by direct cell-cell contact, mediated in part by activation of TGFβ [18], [24].
This difference should be ascribed to the absence of OprF which is an adhesin required for contact mediated cytotoxicity [32], [33] and has intrinsic cytotoxic potential [35], [36].
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The ability of one FBM neuron to direct the migration of another is presumably mediated through cell-cell contact-mediated signaling.
Hattori, M., Osterfield, M. & Flanagan, J.G. Regulated cleavage of a contact-mediated axon repellent.
Whether Sema3E/PlexinD1 signalling is enhanced in parallel with the recently described contact-mediated migration of CR cells is a question that warrants further study.
Contact-mediated mechanisms and the release of substances into the medium both played a role in supporting axon regeneration.
Gondek, D. C., Lu, L. F., Quezada, S. A., Sakaguchi, S. & Noelle, R. J. Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism.
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