Sentence examples for contact bound from inspiring English sources

However, Ser237 does not contact bound benzylpenicillin.

In contrast to the NA of the 1957 pandemic virus, the only available sequence of the N1 NA of the 1918 pandemic virus [ 39] shows no substitutions of the six key amino acids in the hemadsorption site that contact bound sialic acid.

Importantly, in each case of human infertility caused by septin mutation, the mutation affected a residue predicted to contact bound nucleotide and either blocked GTP binding or hydrolysis, leading to the complete failure to assemble a filamentous septin ring called the annulus (Kuo et al. 2012).

And though at every point he faces hostility directed against his queerness, it also gives him access to a covert network of contacts, bound by an often secret sympathy.

In a different GTP-binding protein, the α-subunit of the G protein-coupled receptor GS, a mutation affecting a residue that also directly contacts bound nucleotide confers a testis-specific defect because the mutant protein is stable at 33° but degraded at 37°, suggestive of temperature-dependent conformational changes (Nakamoto et al. 1996).

Given that both the Fe- and Apo- forms of H. pylori Fur have regulatory activity [4], [5] (Fig. 1), five residues that seemed likely to affect the conformation of the metal-binding pocket and/or make direct contact with bound iron (Fig. 2B) were targeted next for mutagenesis.

The cadherin repeat domains often exist as tandem repeats in the extracellular regions; they may mediate cell-cell contact when bound to calcium.

After the VWA domain, 21 CA (Cadherin repeat) domains follow, they occur as repeats in extracellular regions and are thought to mediate cell-cell contact when bound to calcium.

While it directly contacts paromomycin bound to helix 44, its function remains an enigma and its chemical structure remains to be elucidated.

The first two RRM domains of PTB, the RRM domains of nucleolin, sex-lethal, HuD and U2AF all bind nucleic acid as independent modules, while the RRM domains of hnRNPA1, PABP and the third and fourth domains of PTB all form interdomain contacts when bound to RNA.

For example, the rhinovirus is typically acquired by direct contact; it binds to human ICAM-1 receptors through unknown mechanisms to trigger the release of inflammatory mediators.