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In exploratory analyses, we evaluated joint associations with incident diabetes of toenail mercury concentrations and self-reported fish consumption (Supplementary Table 4) or estimated long-chain omega-3 consumption (Supplementary Table 5).
Fiona's memory usage scales linearly with the dataset size (Supplementary Table S2), which is in line with the expected memory consumption (Supplementary Section S2.6).
The Egger test provided no evidence of publication bias at any levels of total coffee, caffeinated coffee, and decaffeinated coffee consumption (Supplementary Table 2).
There was no interaction with several important characteristics, including those related to self-reported alcohol or tobacco consumption (Supplementary Table 1).
Importantly, we found that the presence of ethanol (5%) in the food did not significantly alter larval food consumption (supplementary material Fig. S2); the developmental delay, lethality and reduced body size are therefore not due to lack of nutrition.
In these analyses, the heterogeneity at each level of caffeinated and decaffeinated coffee consumption decreased significantly, with even more inverse results for both caffeinated and decaffeinated coffee consumption (Supplementary Fig. 3).
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The extra point is added for consumption of red and processed meats below the median intake (Supplementary Appendix 3).
Consequently, CO2 emissions originating from electric power consumption and supplementary fuel is expected to be reduced by about 40% annually compared with emissions from a conventional plant; in addition, the cost of fuel and electricity can be reduced by 23 million yen.
We quantified three additional factors that could affect consumption of supplementary food in order to control statistically their potential effect.
Consumption of supplementary food did not fluctuate with expected temporal variations in the energy needs of different sex and age classes.
Similarly, there was a very good correlation between intracellular ATP loss treated with 2-DG and the basal glucose consumption rates (Supplementary Figure 3A).
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