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On average, continuous users consumed higher doses of supplements than initiators or discontinuers for most supplements, although doses were often still in excess of recommended levels.
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For example administration of coumestrol and equol to newborn mice can enhance methylation and produce inactivation of the proto-oncogene H-ras [ 37], and DNA methylation patterns is altered in 8-week-old mice that consumed high doses of genistein [ 38].
Within the past year and a half, researchers have found that only male rats have a biochemical condition in the bladder that lets crystals form when they consume high doses of saccharin.
Rats allowed extended daily access (6 h) to cocaine, consume high doses of the drug and escalate their cocaine intake over days, resembling the pattern of cocaine use seen in human addicts.
The cost imposed by the consumption of nicotine in our experiments may explain why healthy bees did not constantly consume high doses of nicotine (Tiedeken et al., 2014).
There was a trend towards a significant genotype × time interaction before week 7 (F[2,44] = 2.9, p = 0.066), suggesting that RMOR mice may even have initially consumed higher effective doses of morphine.
I used to take high doses of protein.
Take high doses of corticosteroids.
Conclusions Gastric emptying after a Swiss cheese fondue is noticeably slower and appetite suppressed if consumed with higher doses of alcohol.
Children with egg allergies who consume increasingly higher doses of egg protein the very nutrient they react to appear to gradually overcome their allergies, tolerating eggs better over time and with milder symptoms, according to research conducted at the Johns Hopkins Children's Center and elsewhere.
However, this was reversed from PND26 to PND33 when S-D rats consumed a higher dose of genistein than F344 rats (Table 4).
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