In addition, each author made the following specific contributions: MUY participated in the study design, data acquisition, consultation on statistical analysis, and interpretation of results.
We thank Dr. Karin Wertz at DSM for providing the lycopene and placebo beadlets; Mr. Toyoh Banno Eisai Food & Chemical Co., Ltd., for providing the γ-tocopherol; Dr. John Isaacs for providing the Dunning R3327-H tumor; Dr. Ronald Weigel for his consultation about the statistical analysis; and Sung Eun Choi, Dave Woessner, and Alex Nham for their technical assistance.
We are grateful to Dr Paul Holden (OHSU Department of Orthopaedics) for guidance in the technical aspects of protein extraction, HIF immunoblotting and zymography and to Prof Jung Yoo (OHSU Department of Orthopaedics) for consultation on appropriate statistical analysis.
Prevalence = N diagnosis + (N diagnosis N accepting consultation × N refusing consultation ) N interview × 10 0 The statistical analysis was conducted in SAS version 9.1.3 in Windows XP.
We would like to thank Dr. Frédéric Bouillaud for generously providing us with the stably transfected CHO cells and a critical review of the manuscript (Institut Cochin; INSERM U1016-CNRS UMR 8104; Univ Paris 5, Paris, France) and Dr. David Bickel for his statistical analysis consultation (University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada).
GB participated in the design and coordination of the study, and provided statistical analysis consultation.
Although not included in the statistical analysis, consultation rates prior to 2008 ranged from 0 to 5 per year (1999 2007).
ELHT and PPSW carried out the statistical analysis, in consultation with GML.
TRF and AWL designed the study; MSR designed and carried out the statistical analysis in consultation with TRF and AWL.
