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This review will focus on the construction, refinement, and validation of chemokine receptor models for the purpose of structure-based virtual screening and ligand design.
This review will focus on the construction, refinement, and validation of G-protein-coupled receptor (GPCR) structural models for the purpose of structure-based virtual screening (SBVS) and ligand design.
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Recently developed dynamic experimental techniques offer new opportunities for the use of model-based experimental design in the construction and refinement of predictive models of cellular behaviour.
This information facilitates construction and refinement of structural homology models, and assists protein function predictions.
The Discovery Studio package (v1.7, Accelrys, San Diego, CA) was used for model construction and refinement.
The synthesis, construction and refinement of the BPS was an iterative, cyclical process.
Accurately defining the marker order on chromosomes is crucial for correct identification of quantitative trait loci (QTL), haplotype map construction and refinement of candidate gene searches.
> During the construction and refinement of GEMs, it is often necessary to analyze models that deviate only in a few particular features.
Further, future efforts to develop predictive models of anopheline cell signaling responses, based on iterative construction and refinement of data-based and literature-based knowledge of the MAP kinase cascades and other networked pathways (reviewed in [ 65]), will ultimately be necessary to elucidate the "master signaling regulators" in these biomedically important insects.
Further, future efforts to develop predictive models of anopheline cell signaling responses, based on iterative construction and refinement of data-based and literature-based knowledge of the MAP kinase cascades and other networked pathways will facilitate identification of the "master signaling regulators" in biomedically important mosquito species.
Gill was an innovator in the construction and structural refinement of buildings using reinforced concrete.
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