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We constructed the integrated network of yeast interactions, the yeast interactome, by integrating protein-protein interactions PPIs) and post-translational modifications PTMs).
We then constructed the integrated map by adding SNP markers to the skeleton bin map.
CW constructed the integrated and virtual maps under FWN's close supervision.
By the same procedure, we first constructed the integrated cellular network under heat shock stress for the WT strain yeast.
SR constructed the integrated pathway diagram, contributed to the development of the notation system, participated in the expression profiling and analysis, and helped to draft the manuscript.
BAC: Bacterial Artificial Chromosome; BES-SSRs: microsatellite markers from BAC-ends; FISH: Fluorescence In Situ Hybridization; PCR: Polymerase Chain Reaction; RIL: Recombinant Inbred Lines; SSR: microsatellite locus; STC: Sequence-Tagged-Connector; JMC participated in planning of the studyn, carried out the SSR genotyping, constructed the integrated map and drafted the manuscript.
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Quite interestingly, we find that it is not necessary to save the integration details in order to construct the integrated ontology.
We here provide a systematic and efficient method to integrate different kinds of omics data to construct the integrated cellular network via microarray data based on coupling dynamic models and statistical assessments.
Our goal is to construct the integrated cellular networks in which transcription regulations and protein-protein interactions are integrated.
Based on the high density saturated genetic map [ 20] and SNP map [ 21], we integrated 698 SSR, 219 InDel, 36 SV and 386 SNP markers to construct the integrated map.
In this study, we integrated different kinds of omics data and developed a systematic method to construct the integrated cellular network based on coupling dynamic models and statistical assessments.
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