DOI: http://dx.doi.org/10.7554/eLife.05289.014 To better understand how binding of BCL2 family proteins to Beclin 1 may inhibit MK2-mediated phosphorylation, we constructed a structure-based model to determine whether both BCL2 and MK2 could bind simultaneously to Beclin 1.
To retrieve even more distant UlaGL sequences, we first constructed a structure-based sequence alignment using the superimposed homologous structures identified with PDBeFold [ 30] (see below) and used this alignment, with 5 sequences and 232 aligned amino acid residues, as seed for the calculation with HMMER v. 3.0 (http://hmmer.org/) of a profile hidden Markov model (HMM) [ 33].
Their intention is to design and construct a structure or carry out works.
As shown in a schematic diagram, one needs to construct a structure above the highway road using firm RCC beams or stainless steel structure materials.
Depending on the site location, one can construct a structure avoiding the trees, thick vegetation, level crossing, or other obstructing structures en route.
To better understand how various inhibitors might block the interaction of VCAM and fibronectin with α4β1, we began constructing a structure model for the integrin α4β1 complex.
Given the observed audio-visual parameters, Oa, Ov, and their corresponding HMM, the Fused HMM was proposed to construct a structure linking the component HMMs together by giving optimal estimation of the joint probability.
By constructing a structure operator quite different from that ofZhang and Baker (2000) and using the Schauder fixed point theory, the existence and uniqueness of the solutions of the series-like iterative equations with variable coefficients are discussed.
Among technologies developed for tissue engineering and regenerative medicine, organ printing technology is one of the most attractive and powerful for use in constructing a structure that mimics a real 3-D tissue or organ.
After nearly eight years of universally accepted policy failures and incompetence bordering on criminality, the ability of political strategists to use fear and complacency as tools upon which to construct a structure worthy of a Hollywood studio set, all show, no functionality, is quite simply astonishing.
To be able to accommodate the CHOs within their zones, the community usually constructs a structure that serves as a CHC (clinic) and as a residence for the CHO.
