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We constructed a background distribution for these scores by simulating pairs of random gene lists.
By repeating this process 5000 times and calculating the histogram of x, we constructed a background distribution P(x = k), estimating the probability to get by chance k processes with hyper-geometric enrichment p-value
We therefore constructed a background image by extrapolating the local minima across the entire array.
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We also needed to construct a background set of non-pre-miRNA hairpins to estimate the background noise.
Ever since, full 'humanity' is constructed against a background of preconditions (citizenship, class, gender, race, religion, sexuality) which exclude the majority of human beings.
Note that the wild-type control is different in the case of the set1Δ and H3K4R strains because the histone mutant is constructed in a background where only one copy of the histone H3 is retained.
To gain further insight into the plasmid loss defect of PS1-hp mutants, a conditional Mcm4p PS1-hp and a Mcm5p PS1-hp double mutant was constructed in a background containing the temperature-sensitive allele mcm5 -461 (Dalton and Hopwood 1997; Leon et al. 2008).
Nevertheless, sufficient information was obtained to construct a custom background, which takes into account the fact that the sea bass transcriptome is only partly represented onto the microarray, and to identify biological processes that are significantly enriched among differentially expressed genes (see Table 4).
Because the deletion collection of nonessential yeast genes was made in the BY strain background, we constructed a query strain containing mps3 ∆ covered by MPS3 on a URA3 -marked centromeric plasmid in this background for use in high-throughput studies.
Using V3 as a background, we have constructed a combinatorial library using the next eight highest frequency mutations.
Fascinated by a Pontormo painting of the Visitation, Viola constructed a cityscape based on its background and got three women to enact a simple scene in it.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com