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After we construct a regulation list, we compute the R2 score for the gene pairs in the regulation list.
As a most recent development, micro-RNA (miRNA) not only has promising clinical applications in cancer diagnosis and treatment, but also could as competing endogenous RNAs (ceRNA) to construct a regulation network to understand regulatory pathways in cancer [ 3].
Construct a regulation list 1: Compute R1(A, B, t1, p) between gene A at time point t1 and gene B at time point t1 + p for all pairs of genes.
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In our study, we identified and constructed a regulation network of differentially expressed IPF miRNAs and EMT genes.
Importantly, we have constructed a regulation network based on co-expression patterns of the expression profiles upon multiple stresses performed in this study.
To explore the role of miRNAs on regulating EMT in the process of IPF, we identified the differentially expressed miRNAs from the IPF miRNA expression profile compared with the control group and constructed a regulation network of differentially expressed IPF miRNAs and EMT genes.
Moreover, the goal of our system is to construct a gene regulation network from literature.
The ultimate goal of our work is to construct a dynamic regulation network of pollen development.
Generally speaking, epigenetic modifications and miRNAs could construct a mutual regulation network to contribute to diseases.
It is worthwhile to note that epigenetic modifications and miRNAs could construct a mutual regulation network with EpimiR.
TF-DNA binding (chip-chip) and protein phosphorylation data were used to construct a cell cycle regulation network.
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