It should be noted that the constriction mechanism itself in TKO mice remains intact, as demonstrated previously by application of the parasympathetic agonist carbachol [49].
The "cranial constriction" mechanism, which is generally thought to represent "classical" CMI, is believed to result from underdeveloped occipital bones resulting in a posterior fossa (PF) that is too small to accommodate the normal sized cerebellum [ 4, 5].
DOI: http://dx.doi.org/10.7554/eLife.08828.020 10.7554/eLiFigure28 figuregure 8—figure supplement 1. Computational results of simulations of mitochondrial constriction mediated by actin polymerization and actin constriction mechanisms.
Is this suggesting that we should revisit the 'vaso-constriction' mechanism of action?
Conclusions: We suggest that brewery dust extracts cause a dose-related airway smooth muscle constriction by nonimmunologic mechanisms involving a variety of airway mediators and, possibly, cholinergic receptors.
Myogenic constriction is an important mechanism of blood flow regulation; however, it has never been demonstrated in the human coronary circulation.
Although it is not known how the outer pair of membranes divide, the constriction is performed by a mechanism that is distinct from the mechanism for the inner pair.
This dependence of colloid release and permeability changes on flow velocity and colloid concentration was consistent with colloid retention and release at pore constrictions due to the mechanism of hydrodynamic bridging.
However, the absence of an influence of stress on overall relaxation in BHR (versus control), together with reduced NE-induced constriction, suggests that nonvascular mechanisms are involved in the acceleration of hypertension development seen in this genotype.
While it is currently not obvious which of these or if a combination of the three mechanisms drives constriction, it seems clear to us that constriction, at least in the liposome reconstitution experiments, requires filaments to slide past each other as is depicted in two dimensions.
Epiboly can be controlled by purse string (actinomyosin) constriction and flow friction mechanisms, pulling the enveloping layer (which overlies and envelops the deep cell layer) toward the vegetal pole after 50% epiboly (Behrndt et al., 2012; Cheng et al., 2004; Köppen et al., 2006; Lin et al., 2009; Zalik et al., 1999).
