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Cohesion was categorized into normal (cohesed) or aberrant (primary constriction gap; PCG).
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We have previously defined aberrant cohesion or primary constriction gaps (PCG) as a clear and distinct separation within the DAPI signal occurring between the sister chromatids at the centromere, the site of the primary constriction [ 7].
Chromosome fragile sites (CFS) were first identified in humans as specific regions of constrictions, gaps, or breaks on metaphase chromosomes after cells were exposed to chemicals that inhibit DNA replication (Sutherland 1979).
The reported maximum constriction point of the gap junction sits within the TM domain [10].
However the gap or constriction at 45S rDNA sites on metaphase chromosomes has not been well identified and studied.
To further mimicking the in vivo microcirculation and the role of capillaries, a number of works described the cell deformation using gap shape constrictions [53].
Fragile sites are expressed either as gaps, constrictions or breaks on human metaphase chromosomes [24].
In humans, chromosome fragile sites are regions that are especially prone to forming non-staining gaps, constrictions or breaks in one or both of the chromatids on metaphase chromosomes either spontaneously or following partial inhibition of DNA synthesis [2], [3].
In humans, chromosome fragile sites are regions that are especially prone to forming non-staining gaps, constrictions or breaks in one or both of the chromatids on metaphase chromosomes either spontaneously or following partial inhibition of DNA synthesis and have been well identified.
The fluid flow rate will impact the force applied to each cell as it is deformed through a constriction, whereas the pores or gap dimensions determine the size and deformability of target cells that can be captured by the filter.
Electron propagation states within the transmission gap of the constrictions can be interpreted as quasi-localized states.
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