The solution approach utilizes Discrete Event Simulation (DES) to model the performance measure under consideration of process constraints and variability.
Adjacency constraints increased variability in the amount of forest interior and edge, but had a marginal effect on the total amount.
Static design optimizations are unable to consider the physical generator operating constraints, seasonal variability and non-coincidence in electric, heating, and cooling demands.
Authors claim that the relative contributions of the expression level and the domain-specific structural-functional constraints to variability of evolutionary rates are *closely comparable*.
In summary, introducing the coordination of carbon and nitrogen utilization [ 20] as an additional physiological constraint, growth variability is the only significant component of flux variability in the physiological range of glucose, oxygen and ammonia uptakes.
With this model of the pathogenic strain we arrive to the same general conclusions, namely, introducing the coordination of carbon and nitrogen utilization as an additional constraint, growth variability is the only significant component of flux variability in the physiological range of glucose, oxygen and ammonia uptakes (see results in Additional file 8).
The penalty function Q represents the strength of the constraints against the variability in the first derivative of the ϕ-functions as follows: (9 where the index j runs across all the Delaunay triangles with areas Δ j ; and and is the function value of the vertex coordinate and, respectively.
Such a networking model, taking into account cortical and subcortical anatomic constraints, explains interindividual variability in physiology and after brain damage, particularly in aphasiology – e.g. double dissociations during electrostimulations, as comprehension versus naming disorders, semantic versus phonemic paraphasias, or syntactic disturbances versus anomia.
The LRR domain is likely involved in the binding of the SUB ligand and thus seems an essential aspect of SUB activity, placing constraints on sequence variability.
These plots therefore demonstrated that despite the overall plasticity of the HIV-1 proteome, there are sequence constraints that constrict variability in certain regions within several proteins.
