Importantly, cancer cells often acquire mutations that compromise the apoptotic process, allowing these cells to both escape normal growth constraints and to become resistant to many anti-cancer drugs, resulting in the emergence of drug-resistant malignancies [ 3].
But as the the density of PUs increases, the interference of PUs becomes large, which causes the constraints to SUs become strict.
Note that a constraint is said to become an active constraint when the power distribution is such that the inequality (e.g., (3) or (4)) becomes exactly equal.
Care group A's director explained that the care group had a very good working relationship with health insurer X. Interviewees also pointed out that the financial pressure in the national health sector made cooperation more urgent and therefore easier to accomplish, amongst other things, because financial constraints motivated people to become more innovative.
Moreover, this constraint is likely to become less severe as the technology advances.
This constraint is expected to become increasingly suboptimal (i.e., contact calls will be increasingly inaudible) as aye-ayes become more widely dispersed as a result of habitat fragmentation.
Though word had already spread around town wartime constraints caused the subject to become taboo rapidly.
In an interdependent world confronted with serious ecological constraints, zero-sum competition to become the winningest fossil fuel "superpower" means, to borrow Garrett Hardin's famous phraseology, a catastrophic tragedy of the commons and the ruin of all.
For biotechnological production of R-HAs on a large scale, it is important to not only consider yield, product concentration, and productivity, but also the cost of substrates and downstream processing, which are crucial constraints for a process to become economically viable.
The assumption of normalising constraints that cause some interactions to become more competitive as a side effect of others becoming less competitive is thus important to the results that we have shown.
