Overall, we found no recurrent statistical support for positive selection on specific sites or branches acting on the AR pathway in teleosts, indicating conservation or constraint acting on the pathway.
Only one of these less variable pathways (tRNA charging) had a lower than average level of gene duplication, suggesting that the constraints on these pathways are not associated with altered duplication patterns.
Increasing shuttle activity, by overexpression of a key component of the shuttle (Alarar1), may remove the constraint on the glycolytic pathway thus allowing a higher flux through glycolysis and NADH production.
Since we imposed a stringent constraint on the within-pathway synthetic lethal interactions (α = 0.01; see Method), we found that only one of the pathways we identified have within-pathway synthetic lethal interactions.
This is one victory on the pathway to justice.
Despite the overlapping functions of the fMAPK pathway and RPI1, the organization of these genes into complex networks likely imposes constraints on the loss of one or the other of these activation pathways.
One of the most widely discussed issues across all roles and positions was the participant's perception of the institutional constraints on their career pathway opportunities.
The PMN addresses this limitation by presenting additional constraints on the choice of regulators, requiring a physical pathway that connects it to some of the target genes.
The minimum-energy pathway along RC2 subject to constraints on the other coordinates (RC1, RC3, RC4) traces out a pseudo-one dimensional stripe through a four-dimensional space.
After that, in the genomic domain, as most enrichment analyses placed constraints on genetic pathways of sizes from 10 to 200 [18], we cut the dendrogram at half of its height to build genetic clusters (i.e., GSs) whose sizes are mostly within the above range.
