Although there appeared to be the beginnings of a trend indicating improved outcomes with Celsior, we had insufficient studies using Celsior solution, due to the strict constraints of our inclusion and exclusion criteria, to determine if this solution performed better when controlling for CIT.
Systematic reviews including this one are limited by the constraints of the inclusion criteria, in this case the terms and the date of the review period (2005 June, 2012).
Although our study required manual chart review to conform to the clinical constraints of our inclusion criteria, the i2b2 framework provided multiple important advantages that warrant mention.
Improvements include the coupling of equipment and network modelling across many buildings, detailed CHP operational constraints, the inclusion of network heat losses, and improved modelling of thermal storage.
In addition, the constraints of rigid exclusion and inclusion criteria applied to RCTs may limit the ability to extrapolate the results to a wider population.
Traditional barriers to introduction of new methods in health education and oral health strategies in the field include time constraints, inclusion of dental procedures [ 16], lack of knowledge [ 8], and confidence related to the proposed activities [ 18].
For the ease of presentation, we also disregard a budget constraint, the inclusion of which would not change our qualitative results.
The VLS was designed as a "pragmatic" trial in which the intervention to be tested is overlaid on the background of usual clinical practice, with a minimum of study-related practice constraints, liberal inclusion, and few exclusion criteria.
Cross tree constraints: typically inclusion or exclusion statements of the form "if feature F is selected, then features A and B must also be selected (or deselected)".
This constraint allowed the inclusion of gaps of up to four contiguous windows (or 20 kb) containing less than ten piRNAs each that could continue the cluster.
