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By mimicking key processes of Darwinian evolution in the test tube, the functions of enzymes can be explored free from the constraints of function within a living system.
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Overall scheduling length (i.e., makespan) is the main concern in system performance, whereas deadlines represent the major timing constraints of functions.
The security requirements are one of the non-functional requirements, which act as constraints on functions of the system.
But it put the constraints of Dirac function on the boundary.
The coefficients of the parameter functions are simultaneously estimated by maximizing a penalized log-likelihood function that determines the optimum trade-off between the goodness of fit to the data and uniformity constraints of the functions (i.e., facets of each piecewise linear function being as flat as possible).
These symmetries, which are given by the constraints of analytical functions, look rather reasonable.
The land market also faces a number of constraints to functioning freely and effectively.
This suggests epistatic constraints in evolution of function in IPMS and HCS-lys enzymes.
We hypothesise that this trend is due to expensive amino acids being conserved at certain sites due to selective constraints on structure of function, while the choice of amino acids in divergent sites is more affected by cost selection (see Discussion).
Since AR correlates with the constraint of graft function, it is of major importance to counteract its effect immediately.
Compared with lncRNAs functioning in cis to regulate local genes, the evolutionary constraints of HOTAIR that function in tran is more intriguing.
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