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Due to difficulties in the fabrication of the tungsten target and foreseen mechanical constraints (large stresses due to the concentrated energy deposition), it is more convenient to use tantalum instead of tungsten.
An improved damper geometry with air channels was developed to address contradictory design constraints: large sensing parallel-plate area is desirable for a significant readout capacitance as well as reduced damping coefficient.
In order to address these constraints, large experiments consisting of multiple neuronal differentiations from multiple independent hiPSC lines from multiple patients would have to be performed.
When busy, community nurses' workload may be very heavy due to time constraints, large amount of documentation or due to taking on extra clients and responsibilities when staff are on leave or sick.
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However, scalability is still an issue due to memory constraints or large databases, with very large database segmentation leading to additional performance decline.
Aslef, the train drivers' union, said that the likelihood of a successful general strike will be limited by legislation governing strike ballots, which imposes considerable practical constraints on large walkouts by requiring that each ballot is backed by significant amounts of detailed data.
I then consider astronomical evidence for and constraints on large compactified dimensions.
Small businesses often face resource constraints that large businesses are able to surmount.
Moreover, some recent multimedia applications require the network to satisfy specific throughput and delay constraints for large data sizes.
In problems with many solutions, where constraints are large, these drawbacks become so important that users often replace AC-4 by AC-3 [8], a non-optimal algorithm.
The conflicting objectives together with nonlinear constraints and large numbers of variables make such problems difficult to solve with conventional methods.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com