Although constraints are useful in explaining how children limit possible meanings when learning novel words, the same constraints would eventually need to be overridden because they are not utilized in adult language.
In addition to providing a novel explanation to one of the most fundamental questions in evolutionary immunology, and highlighting the critical role that evolutionary constraint might play in explaining the origin of evolutionary novelty, the hypothesis also emphasises the fact that immunity manifests as a system-level phenomenon.
A concern of many critics of adaptationism is that this treatment of constraints undervalues their role in explaining evolutionary form and novelty.
Might this provide a means to tease apart the confounding effects of the environment, geometric constraints, and species tolerances in explaining biogeographic patterns [25], [26]?
We observed that genes classified as specific to the embryonic gonadal category were involved in significantly more interactions than those specific to the adult gonads, suggesting that lack of pleiotropy-mediated constraint may play some role in explaining the tolerance for evolutionary divergence of adult gonad specific genes when compared to those of other tissues and stages.
Thus there appears to be evidence that the accelerated evolution observed in later stages of development is driven by unique selective pressures such as sexual selection (but see also [ 67, 68] for examples of theory and empirical evidence suggesting relaxed selective constraint has a large effect in explaining the rapid evolution of genes with sex-limited expression).
The above analysis shows that the efficiently allocating hypothesis and budget constraints theory may be more relevant in explaining the impact of sibling sex composition on educational attainment.
In explaining the decision to axe Hoggard, Yorkshire cited financial constraints and new regulations that will reward counties that favor younger players.
He is less strong in explaining the complex background reality, such as the general constraints and individual slips of regulators and pharma companies' employees".
In explaining its gloomier view, the report pointed to rising fuel and commodity prices, combined with supply constraints caused by the recent earthquake and tsunami in Japan.
