These findings unravel physical constraints fitting a spatially dependent least-action for water coordination, introduce a molecular design concept, and herald the advent of water-tight peptide-based materials with sufficient backbone exposure to remain flexible.
Next, we imposed additional constraints fitting the experimentally observed AP-1 DNA binding activity dynamics, and then concluding with the constraint that model predictions match the TH mRNA dynamics.
FBA employs a linear programming (LP) strategy to generate a flux distribution that is optimized toward a particular 'objective', normally maximal cell growth, subject to a set of underlying physicochemical and thermodynamic constraints fitting experimental data on changes at nutritional and metabolic levels [ 43].
The shell of a supercavitating torpedo must be designed to survive extreme loading conditions (depth pressure and thrust loading), meet frequency constraints, and fit inside the cavity generated by the cavitator.
After taking into account the devices' interfaces to the outer world, the designer faces severe constraints to fit energy storage elements such as batteries, inductors and capacitors and meet the desired weight, size, shape and performance goals for the intended application.
An expressed concern of some of the military product developers was that the weight of the LSTAT pan and the configuration of the LSTAT as dictated by the size constraints to fit in military aircraft would make the LSTAT awkward to use during patient care.
If we were to free the room from its constraint to fit within this toolbox, perhaps new combinations could arise and, with them, not only new spatial diagrams, but new social ones.
This study utilized two approaches to analyze MDSFR measurements: (1) a single wavelength MDSFR analysis, which extracts μ′ s and γ independently for each wavelength; (2) a spectrally-resolved MDSFR analysis that utilizes prior knowledge of the wavelength dependence of μ′ s as a constraint to fit μ′ s and γ over a selected wavelength range.
"Topological optimisation", as the process is known, uses complex algorithms to conjure up a shape that best satisfies a set of structural constraints: it fits into a prescribed space; makes allowances for movement; withstands expected loads; and does all this using the least amount of material.
