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In the context of the phase A of this programme, many system options are still widely open: detailed requirements, constraints and hypotheses are not yet fully stabilised.
Future studies are necessary to corroborate these findings, yet we believe that the current results and interpretations will provide valuable constraints and hypotheses for future research.
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It also makes possible to discuss the feasibility of the vehicle with regard to different multidisciplinary constraints and technology hypotheses for the heat shield.
Notice that our FBA model is based solely on metabolic constraints and the hypothesis of maximal growth, and includes no knowledge about regulation, signaling or any other processes occurring within the cells.
For further experimental evidence supporting the soft constraints and minimum memory hypotheses, see [24] and [23].
The compilation needs to be an expeditious succinct statement of – depending on context – objective, constraints, hypotheses and risks, and of the appropriate actions, controls and tests.
This provides a first validation for the model constraints and also for the hypothesis of maximal growth as cells objective, as it seems able to capture (partially, at least) the metabolic regulation that P. pastoris has evolved and which determines its behavior in the presence of these substrates.
However, a gradient in these divergence rates over development is predicted by both the developmental constraint and selection opportunity hypotheses and thus evidence supporting either or both will be considered below.
The generated procedures respect topology constraints, designer's hypotheses and design constraints.
Developmental and genetic constraint hypotheses do not invoke causal processes in the same way that adaptive hypotheses do.
The significance of the latter result is likely biased due to the different number of topologies explored between the null and test constraint hypotheses [ 37].
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