This process resulted in a list of 127 proposed MCZs designed to conserve biodiversity and reconcile socioeconomic concerns, however, citing budgetary constraints and evidence-related issues, the UK Government has proceeded with a tranche approach, designating far fewer sites than stakeholders had expected.
The resulting map serves as a visual representation of the policy process and is used to illustrate the core actors, linkages, influence level, bottlenecks, incentives, and capacity constraints and for evidence-based and inclusive policy processes.
Although GRADE has been considered by some as being too resource intensive and difficult to apply in public health guidance, especially under time constraint and when evidence is limited [ 20], it is recognized by others to provide a systematic approach, promote dialogue, and ensure documentation of the process that leads to a given recommendation [ 21, 22].
Analysis of d N/d S revealed wide variation in selective constraint between genes, and evidence that highly expressed genes, more "multifunctional" genes, and those with more paralogs were under elevated purifying selection.
Previous studies have demonstrated that highly conserved intronic regions are correlated with functional constraints and can be evidence of a hidden class of abundant regulatory elements [ 59].
Malnourished elective major surgery patients are not routinely given nutrition support (NS) preoperatively in the Philippines owing to financial constraints and lack of evidence of benefit in the local patient population.
Based on the paleo-magnetic constraints, geological evidence and 40Ar/39Ar and U Pb dating, it can be assumed that in the southern part of the Ordos Basin, the Qinling Ocean finally closed during the Late Jurassic-Early Cretaceous period.
The concept of learning, the acquisition of knowledge and the exercise of creative imagination within the constraints of evidence and reason, has been almost fatally devalued.
In the context of increasing budget constraints and rising demands for evidence-based health spending, evidence on effectiveness alone is insufficient for policy making; in addition to knowing what works and in what context, information on the economic costs and consequences of any intervention is required.
Contrary to this prediction, in regions with reduced recombination, where ω is higher, GC content is lower (figs. 3 and 4 a), and evidence of relaxed constraints on nonsynonymous sites also comes from these regions (fig. 4 d).
