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Taken together, these findings suggest that the active site residues forming the small pocket are mainly engaged in the binding step but not significantly involved in the catalytic step, which may provide insights into how to design a rational strategy for engineering of the small pocket to relieve the steric constraint toward bulky substituents.
The Galilean quantities would be of no interest to an Aristotelian who treats the stone as falling under constraint toward the center of the earth (Kuhn 1962, 123).
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The institutional barriers and constraints toward higher efficiency are described.
The findings obtained in this study, not only regarding the mainshock but also for the whole sequence of fore- and aftershocks, can serve as useful constraints toward a better understanding of the physics of the seismo-genesis and the complex seismo-tectonic dynamics of the region.
That increased constraint points toward projected sea level rise lying at or near the upper range of current projections, more than a meter by the end of this century under business-as-usual carbon emissions.
With this, we show that the sequences under SELEX constraints shift toward less stable predicted secondary structures and change slightly in nucleotide content with each successive round of Neutral SELEX.
In birds, the small genome size and low TE content suggest that loss of certain TE families might be a consequence of general constraints acting toward a reduction of noncoding DNA content in the genome.
Instead, a very broad endothermic curve ranging from 90 °C to 172 °C shows up, suggesting that the stretched chains in a filament with severe dimensional constraint relax slowly toward isotropic state over broad range of temperature.
Taken together, these data agree with the conservation and functional constraint of PPARα toward evolution (Fig 1 and Additional file 3: Fig S3).
This finding is of significance as it highlights the role of external constraint on microstructure control toward property modification.
The factors were classified into three categories: motive, constraint and fishers' attitude toward resource use and management.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com