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Pyridones were evaluated as an acyclic conformational constraint to replace the aryl ether core of MK-4965 (1) and the more rigid indazole constraint of MK-6186 (2).
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This paper proposes a novel adaptive volume constraint algorithm (AVC) to replace the fixed volume constraint (FVC) in the traditional topology optimization method, such that a minimum-compliance optimal structure that simultaneously meets the additional displacement limit can be searched.
Time constraints led Niitsuma to replace the character-specific minigames of Cross Generation of Heroes with "Ultimate All-Shooters", an expansion of PTX-40A's minigame.
To conquer nonlinearity of the model, it has been proposed to replace constraints 14, 15 and 16 with Eqs. 18, 19, and 20.
However, these new constraints are posynomial constraints that can be used to replace the nonposynomial ones.
A remedy to this problem is to replace the rank constraint with the nuclear norm constraint, thus solving: begin{array}{*{20}l} & underset{mathbf{L}}{text{minimize}} ~~|mathbf{L}|_ notag & text{subject to} ~~ mathcal{P}_{Omega}(mathbf{M}) = mathcal{P}_{Omega}(mathbf{DL}) end{array} (9).
An operation semantic model is used to replace the geometric constraint model of assembly, which contains several ordered geometric constraints and some engineering restriction conditions.
Therefore, the subspace rotating approach is imposed in our work to replace inequality constraints.
The basic idea is to replace the constraints with a penalty term scaled by a parameter C. The penalty term is the sum of squares of all the constraint violations.
They contend that Partin does not fully understand ORI's regulatory constraints and is unjustifiably seeking to replace ORI's two division directors, whose departure, they write, would be a "disaster".
A new function, a weighted correlation coefficient with coherence constraints (73), was thus introduced to replace linear, nonweighted cross-correlation, and implemented in the refinement program FREALIGN (74).
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