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We suggest that domains of open chromatin may create an environment that facilitates transcriptional activation and could provide an evolutionary constraint to maintain clusters of genes together along chromosomes.
In [7], another optimization method based on cross entropy technique was proposed, where a structural constraint to maintain Doppler tolerance was considered together with the orthogonality conditions.
We have shown above that protein complexes are under constraint to maintain their relative expression levels and exhibit limited expression variability between individuals.
These findings are consistent with understandings of GPCR structure and function given that transmembrane domains are expected to be under strong functional constraint to maintain secondary structure and hydrophobicity.
If in both species the most conserved X-X orthologs are the only two genes with a selective constraint to maintain the ancestral function, the less conserved X-X orthologs may diverge randomly.
If the degree of constraint to maintain the similarity to consensus is similar in the two species, we expect a correlation between the number of differences from consensus in each one of the orthologous sequences.
Similar(52)
A major concern was that the current tariff structure is a constraint to maintaining appreciable stocks of non-drugs.
Despite intense constraints to maintain the status quo back home, Gorbachev and Shevarnadze, made a fundamental determination early on not to use force to maintain the Soviet Union.
Most countries and virtually all developing countries must rely on market mechanisms as well as hierarchical constraints to maintain fiscal discipline.
Multiple axons are tracked from slice to slice through a volume, updating the positions and velocities in the model and providing constraints to maintain smoothness between slices.
Initially this was modelled using a two-component disorder model with constraints to maintain physically reasonable positional and displacement parameters.
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