Exact(2)
Our results reveal an additional open state constraint, reflected by the depolarization-dependent formation of inter-subunit disulfide and metal bridges between R228C in S4 and C136 in S1, thus locking the channels in the open state.
Is the model with the uniform selective constraint (reflected by parameter omega) and raw mutation rates following gamma distribution realistic for nuclear protein coding genes?
Similar(58)
The motivation for studying such a model is provided by a plasma physics problem arising in the modeling of nuclear fusion devices (Braginskii equations), where the two vector unknowns represent ion and electron velocities, the scalar unknown is the electrostatic potential and the divergence-free constraint reflects the physical assumption of quasi-neutrality.
We consider several possible explanations for this association: (1) response to nutrient deficiency, (2) response to substrate salinity (due to growth in coastal mangrove habitats), (3) response to the composition of the Palaeozoic atmosphere, (4) return on investment (long leaf lifespan), and (5) phylogenetic constraint reflecting ancestral conditions.
The three 'supermomentum' constraints in the canonical theory reflect the freedom to drag the metric and matter fields around in various directions on a given three-dimensional spacelike hypersurface, while the 'super-Hamiltonian' constraint reflects the freedom to drag the fields in the "time" direction, and so to the "next" hypersurface.
The direct constraint reflects the need to at least "break even", and get back the payment including interest: 100 + x.
The indirect constraint reflects the desire on the part of the debtor to see a return on the investment: to have increased his or her capital, 100 + x + z.
The age constraint reflects the youngest age bracket of the oldest known fossil seed assignable to the Solanoideae.
This constraint reflects the assumption that we have captured all or most of the relevant endmembers; however in the majority of cases this will not be true.
Thus, genes encoded on the Z. tritici ACs exhibit signatures of activity, host-specific regulation, and selective constraint, reflecting a likely functional role in many cases.
The model's current implementation works well for trees with K ≤ 20, although this is a practical constraint reflecting the rate of MCMC convergence.
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Justyna Jupowicz-Kozak
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