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The second constraint refers to the per-user transmission rate in the BS RS link.
The second constraint refers to the fixed probability of target loss.
· a storage constraint refers to storage requirements of the application, such as persistent storage space.
· a software constraint refers to any software or service utilised by the application, such as Java JDK 1.6.
Various types of constraints are identified: · a hardware constraint refers to hardware requirements of the application, such as CPU or RAM.
· a performance constraint refers to the Quality of Service (QoS) or Service Level Agreement (SLA) that the application need to achieve, such as response time and network latency.
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To this end we utilize a FBA model of E. coli MG1655 metabolic network that takes into account this constraint referred to as 'flux balance analysis with molecular crowding' (FBAwMC) [ 12].
Two optimization procedures were carried out to increase the efficiency of encapsulation, with and without constraints referring to the required mean particle size.
To overcome this computational complexity we derive a set of linear constraints (referred to as linearized capacity regions) which provides a much simpler formulation at a slightly reduced accuracy.
Some of such constraints referred to are obtained explicitly in the manuscript.
The problem of integrating Boolean constraints, referring to the presence or absence of items in rules, was considered by [35].
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