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Our results reinforce the idea that a main constraint on the evolution of cofactor-dependent enzymes is the functional binding of the cofactor.
For example, Giraldeau (1997) describes deviations from optimality in the evolution of photopigments in the rods (as opposed to cones) in the retinas of fish that live in certain sorts of marine environments where a shift in photosensitivity would be useful; Giraldeau uses this deviation to suggest the presence of a molecular constraint on the evolution of the rod cells.
Apparently, selective constraint on the evolution of individual nucleoitide site can be quite weak even within strongly conserved CNSs.
The multiplicity of interacting partners imposes a strong functional constraint on the evolution of hub proteins (Fraser et al. 2002).
Distance conservation between highly divergent organisms implies the extreme constraint on the evolution of the IHR1 lengths, which strongly suggests that their distances are functionally important.
This indirect negatively pleiotropic relationship could therefore act as a constraint on the evolution of both traits in the two sexes.
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Here, we present a geomorphological analysis of the Ethiopian Highlands supplying new constraints on the evolution of river network.
Our findings potentially give new constraints on the evolution of the area and to the general comprehension of back-arc development in collisional regions.
This paper provides constraints on the evolution of the landscape in the Cradle of Humankind (CoH), UNESCO World Heritage Site, South Africa, since the Pliocene.
The additional isotopic measurements will provide quantitative constraints on the evolution of atmospheric composition and on the history of water on Mars.
These models allow mapping of changes in the geomagnetic field at Earth's surface and core-mantle boundary through time, placing constraints on the evolution of the past geomagnetic field.
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